The Drug Enforcement Administration has issued a final rule that, effective June 10, places the following synthetic cannabinoids, in Schedule I of the Controlled Substances Act.

- naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate (NM2201 or CBL2201)

- N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1Hindazole-3-carboxamide (5F-AB-PINACA)

- 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide (4-CN-CUMYLBUTINACA; 4-cyano-CUMYL-BUTINACA; 4-CN-CUMYL BINACA; CUMYL-4CNBINACA; or SGT-78)

- methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3-methylbutanoate (MMB-CHMICA or AMB-CHMICA)

- 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide (5F-CUMYL-P7AICA)

This rule makes permanent the administrative, civil, and criminal sanctions and regulatory controls applicable to schedule I substances on persons who import, export, manufacture, distribute, possess, engage in research on, or conduct instructional activities or chemical analysis of these substances, which include the following.

- any person who engages in the above activities with respect to these substances must be registered with the DEA to conduct such activities

- all importation and exportation of these substances must be in compliance with 21 USC 952, 953, 957, and 958 and in accordance with 21 CFR part 1312

- all labels and labeling for commercial containers of these substances must comply with the requirements of 21 CFR part 1302

- any activity involving these substances that is not authorized under the CSA or the Controlled Substances Import and Export Act is unlawful and potentially subject to criminal penalties

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