The Drug Enforcement Administration is proposing to control the chemical methyl alpha-phenylacetoacetate (also known as MAPA; methyl 3-oxo-2- phenylbutanoate; methyl 2-phenylacetoacetate; α-acetyl-benzeneacetic acid, methyl ester; and CAS Number 16648-44-5) and its optical isomers as a list I chemical under the Controlled Substances Act. This chemical is used in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine.

If finalized, this action would subject handlers of methyl alpha-phenylacetoacetate to the chemical regulatory provisions of the CSA and its implementing regulations. This rulemaking does not establish a threshold for domestic and international transactions of methyl alpha-phenylacetoacetate. As such, all transactions of chemical mixtures containing this chemical would be regulated at any concentration and would be subject to control under the CSA.

Comments on this proposed action may be submitted through June 1.

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